Publications

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Selected recent studies

• Radzishevsky I, Harb L, Odeh M, Maoz I, Saeed A, Lahkar A, Agranovich B, Abramovich I,  Chaudhry FA, Avital A, Liebl DJ, Wolosker H (2026) SLC38A3 deficiency reveals a critical role of blood-derived glutamine in brain development Brain Dec 24:awaf473. doi: 10.1093/brain/awaf473.

 

• Arizanovska D, Dallera CA, Folorunso OO, Bush GF, Frye JB, Doyle KP, Jagid JR, Wolosker H, Monaco BA, Cordeiro JG, Atkins CM, Griswold AJ, Liebl DJ (2025) Cognitive loss after brain trauma results from sex-specific activation of synaptic pruning processes. Brain. Aug 12:awaf293. doi: 10.1093/brain/awaf293.

 

• Sajrawi, C., Odeh, M., Tiwari, A.K., Agranovitch, B., Abramovich, I., Zubedat, S., Saar, G., Shaulov, L., Avital, A., Reznik, D., Benhar, M., Radzishevsky, I., Engelender, S. and Wolosker, H. (2025) Endogenous histidine peptides are physiological antioxidants that prevent oligodendrocyte cell death and myelin loss in vivo. Glia 73(1):122-139.

 

• Odeh, M., Sajrawi, C., Majcher, A., Zubedat, S., Shaulov, L., Radzishevsky, A., Mizrahi, L., Chung, WK, Avital, A., Hornemann, T., Liebl, DJ, Radzishevsky, I. and Wolosker, H (2024) A new type of BBB aminoacidopathy underlies metabolic microcephaly associated with SLC1A4 mutations. Brain Apr 25:awae134. doi: 10.1093/brain/awae134 

 

• Radzishevsky I, Odeh M, Bodner O, Zubedat S, Shaulov L, Litvak M, Esaki K, Yoshikawa T, Agranovich B, Li WH, Radzishevsky A, Gottlieb E, Avital A, Wolosker H. Impairment of serine transport across the blood-brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction. Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2302780120.

• Folorunso OO, Brown SE, Baruah J, Harvey TL, Jami SA, Radzishevsky I, Wolosker H, McNally JM, Gray JA, Vasudevan A, Balu DT. D-serine availability modulates prefrontal cortex inhibitory interneuron development and circuit maturation. Sci Rep. 2023 Jun 13;13(1):9595.

• Liu Y, Wu Z, Armstrong DW, Wolosker H, Zheng Y.Detection and analysis of chiral molecules as disease biomarkers. Nat Rev Chem. 2023 May;7(5):355-373. 

• Tapanes SA, Arizanovska D, Díaz MM, Folorunso OO, Harvey T, Brown SE, Radzishevsky I, Close LN, Jagid JR, Graciolli Cordeiro J, Wolosker H, Balu DT, Liebl DJ.Inhibition of glial D-serine release rescues synaptic damage after brain injury.Glia. 2022 Jun;70(6):1133-1152.

• Wolosker H. and Radzishevsky, I (2021) Promiscuous enzymes generating d-amino acids in mammals: Why they may still surprise us? Biochem J 478(5):1175-1178.

• Bodner O, Radzishevsky I, Foltyn VN, Touitou A, Valenta A, Rangel IF, Panizzutti R, Kennedy RT, Billard JM, Wolosker H. (2020) D-Serine signaling and NMDAR-mediated synaptic plasticity are regulated by system A-type of glutamine/D-serine dual transporters Journal of Neurosci. 40(34):6489-6502

• Balu, D.T., and Wolosker, H. (2020) D-Serine as the gatekeeper of NMDA receptor activity: implications for the pharmacologic management of anxiety disorders. Transl. Psychiatry 9;10(1):184.

 

• Coyle, J.T., Balu, D., and Wolosker, H. (2020) D-Serine, the shape-shifting NMDA receptor co-agonist. Neurochem. Res. 5(6):1344-1353.

 

• Neame, S., Safory, H., Radzishevsky, I., Touitou, A., Marchesani, F., Marchetti, M., Kellner, S., Berlin, S., Foltyn, V.N., Billard, J.M., Wolosker H. (2019) The NMDA receptor activation by D-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle. Proc. Natl. Acad. Sci. U S A 116 (41) 20736-20742.

 

• Balu, D.T., Presti, K.T., Huang, C.C.Y., Muszynski, J., Radzishevsky, I., Wolosker, H., Guffanti, G., Ressler, K.J., Coyle, J.T.  (2018) Serine Racemase and D-serine in the Amygdala are Dynamically Involved in Fear Learning. Biol. Psychiatry 83(3):273-283.

 

• Wolosker H. (2018) The Neurobiology of D-Serine Signaling. Advances in Pharmacology, 82:325-348.

 

• Kaplan, E, Zubedat, S., Radzishevsky, I., Valenta, A.C., Rechnitz, O., Sason, H., Sajrawi, C., Bodner, O., Konno, K., Esaki, K., Derdikman, D. , Yoshikawa, Watanabe, M., Kennedy, R.T., Billard, J.M., Avital, A., Wolosker, H (2018) The ASCT1 (Slc1a4) Transporter is a Physiologic Regulator of Brain D-Serine and Neurodevelopment. Proc. Natl. Acad. Sci. U S A 115(38):9628-9633.

 

• Sason, H, Billard, J.M., Smith, G.P., Safory, H., Neame, S., Kaplan, E., Rosenberg, D., Zubedat, S., Foltyn, V.N., Christoffersen, C.T., Bundgaard, C., Thomsen, C., Avital, A., Christensen, K.V., and Wolosker, H. (2017) Asc-1 transporter regulation of synaptic activity via the tonic release of D-serine in the forebrain. Cerebral Cortex 27: 1573-1587.

 

• Wolosker H, Balu, D., Coyle, J.T (2016) The rise and fall of D-serine-mediated gliotransmission hypothesis. Trends in Neurosci. 39, 712-721.

 

• Kolodney, G., Dumin, E., Safory, H., Rosenberg, D, Mori, H., Radzishevsky, I and Wolosker, H. (2015) Nuclear compartmentalization of serine racemase regulates D-serine production: Implications for N-methyl-D-aspartate (NMDA) receptor activation. J. Biol. Chem. 290: 31037-31050.

 

• Safory, H., Neame, S., Shulman,Y., Zubedat, S., Radzishevsky, I., Rosenberg, D., Sason, H., Engelender, S., Avital, A., Hülsmann, S., Schiller, J. and Wolosker, H. (2015) The alanine-serine-cysteine-1 (Asc-1) transporter is a regulator of glycine metabolism and glycinergic inhibitory transmission. EMBO Rep. 16(5):590-8.

 

• Le Bail, M., Sacchi, S., Yatsenko, N., Martineau, M., Radzishevsky, I., Conrod, S., Ouares,K.A., Wolosker, H., Pollegioni, L., Billard, J.M., Mothet, J.P. (2015) The identity of the NMDA receptor co-agonist is synapse specific and developmentally regulated in the hippocampus. Proc. Natl. Acad. Sci. U S A 112(2):E204-13.

 

• Dikopoltsev, E., Foltyn, V.N., Zehl, M., Jensen, O.N., Mori, H., Radzishevsky, I,, and  Wolosker, H. (2014) FBXO22 is Required for Optimal Synthesis of the NMDA Receptor Co-agonist D-Serine J. Biol. Chem. 289(49):33904-15.

 

• Ehmsen, J.T., Ma, T.M., Sason, H., Rosenberg, D., Ogo, T., Furuya, S., Snyder, S.H., and Wolosker, H. (2013) D-Serine in Glia and Neurons Derives from 3-Phosphoglycerate Dehydrogenase.  J. Neurosci 33(30):12464-12469.

 

• Rosenberg, D., Artoul, S., Segal, A.C., Kolodney, G., Dikopoltsev, E.,  Radzishevsky, I,  Foltyn, V.N., Inoue, R., Mori, H., Billard, J.M., Wolosker, H. (2013) Neuronal D-serine and glycine release through the Asc-1 transporter regulates NMDAR-dependent synaptic activity.  J. Neurosci  33(8): 3533-3544

 

• Wolosker H. and Radzishevsky, I (2013) The serine shuttle between glia and neurons: Implications for neurotransmission and neurodegeneration. Biochem. Soc. Trans. 41, 1546-1550.